Blar i forfatter "Vasiliauskaite, Kotryna"

Viser treff 1-3 av 3

    • AXL inhibition improves BRAF-targeted treatment in melanoma 

      Nyakas, Marta Sølvi; Fleten, Karianne Giller; Haugen, Mads Haugland; Engedal, Nikolai; Sveen, Christina; Farstad, Inger Nina; Flørenes, Vivi Ann; Prasmickaite, Lina; Mælandsmo, Gunhild Mari; Vasiliauskaite, Kotryna (Journal article; Tidsskriftartikkel; Peer reviewed, 2022)
      More than half of metastatic melanoma patients receiving standard therapy fail to achieve a long-term survival due to primary and/or acquired resistance. Tumor cell ability to switch from epithelial to a more aggressive mesenchymal phenotype, attributed with AXL<sup>high</sup> molecular profle in melanoma, has been recently linked to such event, limiting treatment efcacy. In the current study, ...

    • Fibroblast-induced switching to the mesenchymal-like phenotype and PI3K/mTOR signaling protects melanoma cells from BRAF inhibitors 

      Vasiliauskaite, Kotryna; Fleten, Karianne Giller; Barkovskaya, Anna; Nygaard, Vigdis; Haugen, Mads Haugland; Engesæter, Birgit Øvstebø; Mælandsmo, Gunhild; Prasmickaite, Lina (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      The knowledge on how tumor-associated stroma influences efficacy of anti-cancer therapy just started to emerge. Here we show that lung fibroblasts reduce melanoma sensitivity to the BRAF inhibitor (BRAFi) vemurafenib only if the two cell types are in close proximity. In the presence of fibroblasts, the adjacent melanoma cells acquire de-differentiated mesenchymal-like phenotype. Upon treatment with ...

    • Metabolic reprogramming supports the invasive phenotype in malignant melanoma 

      Bettum, Ingrid Johanne; Gorad, Saurabh Sayajirao; Barkovskaya, Anna; Pettersen, Solveig; Moestue, Siver Andreas; Vasiliauskaite, Kotryna; Tenstad, Ellen; Øyjord, Tove Ragnhild; Risa, Øystein; Nygaard, Vigdis; Mælandsmo, Gunhild; Prasmickaite, Lina (Journal article; Tidsskriftartikkel, 2015)
      Invasiveness is a hallmark of aggressive cancer like malignant melanoma, and factors involved in acquisition or maintenance of an invasive phenotype are attractive targets for therapy. We investigated melanoma phenotype modulation induced by the metastasis-promoting microenvironmental protein S100A4, focusing on the relationship between enhanced cellular motility, dedifferentiation and metabolic ...